Extrahepatic manifestations refer to the clinical symptoms and conditions that occur outside of the liver in patients with liver diseases, such as hepatitis or cirrhosis. These manifestations can affect various organs and systems in the body, leading to a wide range of symptoms and complications. Examples of extrahepatic manifestations include skin conditions like jaundice and spider angiomas, joint pain and arthritis, kidney problems, autoimmune disorders, and cardiovascular issues. These manifestations can significantly impact the overall health and quality of life of individuals with liver diseases. Research in this area aims to better understand the underlying mechanisms and associations between liver diseases and extrahepatic manifestations, as well as to develop new diagnostic and treatment approaches to effectively manage these complications. By studying these manifestations, researchers hope to improve outcomes and reduce the burden of liver diseases on patients.